DANIKE DE VILLIERS

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DANIKE DE VILLIERS

Blog #8

28 Apr 2021, 13:53 Publicly Viewable

Blog #8 (SU 5.3)

  1. Compile a table, listing the major effects on every system (cardiovascular, CNS, renal, hepatic and uterus) for all the inhalation anaesthetics. This table is important when it comes to the selection of drugs in certain individuals.

Table of effects of inhaled anaesthetics on body systems.

Inhaled Anaesthetics

Cardiovascular system

CNS

Renal system

Hepatic system

uterus

Halothane

  • Decreased blood pressure
  • Sensitized myocardium for arrhythmogenic effects of catecholamines
  • Fast induction into smooth muscles.
  • Stadium II of anaesthesia is absent.
  • Does not affect the renal system
  • Metabolism takes place in the liver so there is a risk for hepatotoxicity
  • Decreased muscle contractions
  • Used for external twisting of baby

Enflurane

  • Less effects than halothane
  • No sensitization of the myocardium
  • Fast induction of smooth muscles
  • Convulsions can happen

Isoflurane

  • Even less suppression than halothane and enflurane
  • No sensitization of the myocardium
  • Fast induction
  • Fast recovery

Desflurane

  • Less suppressing effects than halothane and enflurane
  • Fast induction and recovery
  • Increased cerebral blood flow
  • Increased intercranial pressure

Sevoflurane

  • Less supressing effects than halothane and enflurane
  • Fast induction and recovery
  • Increased cerebral blood flow
  • Increased intercranial pressure
  • Does not affect the renal system
  • Hepatic metabolism
  • Chemically unstable

Nitrous Oxide

  • No effects
  • Weak anaesthetic
  • Potent analgesic
  • Causes amnesia

  1. Name the major acute toxic effects of the inhalation drugs.
  • Total Central nervous system suppression
  • Total Respiratory suppression
  • Nephrotoxicity
  • Haematotoxicity
  • Malignant hyperthermia 
  • Hepatotoxicity

Reference list

Brand, L. 2021. SU 5 General Anaesthesia. [PowerPoint]. https://efundi.nwu.ac.za/access/lessonbuilder/item/5698352/group/dd46f2da-d3be-402e-9ba7-2c5955cedd9d/English%20power%20point/English%20PP%202021/SU%205.pdf Date of access: 19 Mar. 2021.

Katzung, B.G.  2018.  Basic & Clinical Pharmacology.  14th ed.  California, San Francisco: McGraw-Hill Companies, Inc.