KYLA DU PLESSIS
Kyla du Plessis, 31814425, Blog #11
1 May 2021, 13:04
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Phenothiazines |
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Sub-family |
Piperazine derivatives |
Piperidine compounds |
Aliphatic compounds |
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Example |
Fluphenazine |
Periciazine |
Chlorpromazine |
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Potency |
High potency |
Low potency |
Low potency |
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Side effects |
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Sedation |
Less |
Severe |
Severe |
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EPS |
More |
Little |
Little |
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Alfa-lytic |
Weaker |
Strong: postural hypotension as result. |
Strong: Resulting in postural hypotension. |
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Cardiovascular side effects |
Less |
Cardiotoxic: tachycardia as result. |
Cardiotoxic: Result of tachycardia. |
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Anti-cholinergic side effects |
Weaker |
Strong |
Strong (Brand, 2021). |
- D2-receptors in mesolimbic dopamine pathway are particularly blocked by the typical antipsychotic drugs (Brand, 2021).
- Atypical drugs blocks 5-HT2A-receptors less more potently than blocking D2-receptors, whereas typical drugs works through blocking D2 -receptors more potently that 5-HT2A-receptors (Katzung, 2018).
- D2-receptors (Brand, 2021).
- Haloperidol, because it is a potent D2-receptor blocker which results in a high incidence of extrapyramidal side effects (Brand, 2021).
- The alfa receptors and muscarinic receptors (Brand, 2021; Brink, 2020).
Reference list:
Brand, L. 2021. Antipsychotic drugs and lithium salts. Study unit 9 [pdf]. Unpublished lecture notes on eFundi, FKLG312. Potchefstroom, NWU.
Brink, C.B. 2018. Inleidende Farmako-Fisiologie van die Perifere Senuweestelsel. Study unit 3a [PowerPoint presentation]. Unpublished lecture notes on eFundi, FKLG212. Potchefstroom, NWU.
Katzung, B.G. 2018. Basic & Clinical Pharmacology. 14th ed. International: McGraw-Hill Education.