This means that these agents increase intracellular Ca²⁺ in endothelial cells which leads to synthesis of NO. NO diffuses into vascular smooth muscle and leads to vasorelaxation.
Constitutive enzymes are enzymes that are constantly being made whether it is need or not, they also stay is one area, where Inducible enzymes is made when a substance is present. Their effects is smaller.
Sepsis is caused by an infection. Edotoxin components induce synthesis of iNOS in smooth muscle cells, endothelial cells and more, which leads to widespread generation of NO, can lead to hypotension, shock and in some cases death.
Nitric Oxide (NO).
NOS inhibitors are releases which binds to L-arginine form which NO is synthesised from. This prevents arginine to bind to the three NOS enzymes, which leads to decrease concentration of NO.
A Stimulus can activate the inflammatory mediators, which result in increase in iNOS levels. The vasodilatory effects of NO and effects of COX II plays a role in inflammation and causes red skin, increased vascular permeability which can lead to oedema. Although a disadvantage is that excessive production of NO, causes tissue damage, diseases, asthma and lesions.
In stroke, amyotrophic lateral sclerosis, and Parkinson disease, where excessive NO is involved.