Pain is an unpleasant sensory and emotional experience that serves to alert an individual to actual or potential tissue damage. Pain can be caused by exposure to harmful chemical, mechanical or thermal(heat) stimuli (e.g., acids, pressure, extreme heat) or by the presence of a pathologic process (e.g., a tumor, muscle spasm, inflammation, nerve damage... ). Different people experience pain differently because of the pathways and the type of stimuli people get. Nociceptors are sensory neurons that responds to the stimulus and as mentioned above every single person perceives the stimulus in experiences this in ways that differ. An impaired nociceptor can lead to an individual not reacting to the stimulus and thus not doing anything to remove or solve the harmful exposure that causes the pain as a result the individual endures the pain whereas in an individual with nociceptors working to detect the stimulus the pain is felt or experienced at a greater extend. The management of pain is to relieve pain  by the use analgesics for acute and chronic pain. A referral is made when the patient doesn't react to the strongest analgesics where all weak acting to moderate and strong acting analgesics have been indicated for therapy.