What factors can affect the absorption and spread of sedative-hypnotic drugs?  What is the clinical importance of this?

The lipophyllability (fat solubility), the more lipophilic the faster middle is distributed in body assok is cleaned up.
 

What does redistriation mean and what is its importance?

Due to high lipophyllability, the drugs are fat soluble and therefore quickening is distributed to the surrounding tissues. The drugs move to fat tissue where it causes a "depot" effect and it leads to the slow release light of the drug.
 

How are the BDs metabolized?  Give the different steps in the process.

BD is biotransformed step by step duer liver microsomalous enzymes:
Dealkilering (active metabolites)
Oxidation (Phase 1, cytochrome P450, Akt metabolite molded)
Conjugation (Phase 2, oxyxiated metabolite with glycoonic acid to form inactive metabolite

 

Which BDs are converted to active metabolites?  What is the importance of this?

Diasepam, Chloroceptate, Prasepam, Chlorine diabetes and Ketasolam, the active metabolite has a very long elimination half-life of 40 hours, it contributes to the longer duration of operation of the drug and the suppression of the SSS.

 

Which BDs are not dependent on the cytochrome P45 oxidative enzymes for metabolism?  What are the benefits of this?

Oksasepam, Lorasepam, Temasepam and Lormetasepam, it is beneficial in people with reduced cytochrome P450 activity. (e.g. The Elderly, neonate, liver cirrhosis and tinge with P450 enzyme inhibitors)

 

What is enzyme induction?  Which of the sedatief hypnotic drugs is known for this?  What is the clinical importance of this enzyme induction?

Phenobarbitoon, Carbmamaepine – auto induction, it induces their own metabolism