What are the possible mechanisms involved in the occurrence of tolerance to chronic alcohol intake?

Mixed function oxidases increase with chronic alcohol use and can therefore cause tolerance

What are the toxic effects of chronic alcohol consumption on the liver and hepatic metabolism?

Toxic effects are cirrhosis decrease in liver function, increase enzyme activity of the liver and hepatitis.

What is Wernicke-Korsakoff-syndrome and how is it treated?

It is a syndrome characterized by a decrease in thiamine caused by alcohol abuse and it is treated with vitamin b 1

Fully explain the foetal alcohol syndrome.

Foetal alcohol syndrome occurs when a mother consumes alcohol while she is pregnant this causes the baby to have growth abnormalities and most commonly retardation is seen mostly in the first trimester of pregnancy

How do the pharmacokinetic interactions of acute alcohol consumption differ from that of chronic alcohol consumption?

Chronic alcohol consumption has allot more negative effects as chronic ethanol increases metabolic transformation of drugs and acute alcohol decreases the metabolism of drugs

Name 4 drug interactions with alcohol where the pharmacological effects of the other drugs are potentiated by alcohol

Vasodilators, hypoglycaemic drugs, aspirin and benzodiazepines.