System

Halothane

Enflurane

Isoflurane

Desflurane

Sevoflurane

N2O

CNS

Fast smooth induction; stage II absent; cerebral blood flow; increased intracranial pressure 

Fast, smooth induction convulsions sometimes; not epileptics 

Faster induction and recovery than halothane 

Even faster induction and recovery than isoflurane; increases cerebral blood flow and intracranial pressure 

Even faster induction and recovery than isoflurane; increases cerebral blood flow and intracranial pressure

Weak anesthetic; potent analgesic & can cause amnesia 

Autonomic

Bradycardia

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-

-

-

-

Cardiovascular

Decreased BP; sensitized myocardium for arythmogenic effects of catecholamines

No sensitization of myocardium; less suppression than halothane

Less suppression than halothane and enflurane; no sensitization of myocardium

Less suppression than halothane and enflurane

Less suppression than halothane and enflurane

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Respiratory

No saliva; bronchial secretions and cough

More suppression than halothane 

Potent suppressing effect; strengthens bc of potent skeletal muscle relaxing effects 

Strong smell; irritate airways and if used as an induction drug it can lead to cough, shortness of breath & laringospasms

Less irritation in airways

Hypoxia 

Musculoskeletal

Skeletal muscle relaxing effects in stage III; increased non depolarizing effects; decreased depolarization effects; post-operative shaking = hypoxia

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-

-

-

No skeletal muscle relaxation  

Kidneys

Decrease glomerular filtration & urine flow

Decrease glomerular filtration & urine flow

Decrease glomerular filtration & urine flow

Decrease glomerular filtration & urine flow

Decrease glomerular filtration & urine flow

Decrease glomerular filtration & urine flow

Liver

Hepatoxic

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-

-

-

-

Uterus

Decreased muscle contraction

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-

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