1. How does the sensitivity for blockade by a LA compare regarding the following types of fibres:
   1. myelinated fibres with unmyelinated fibres - Easily blocked
   2. pressure/touch nerves with the dorsal nerves that transmit pain impulses - Activated pain fibres are fired faster but Las block the pain sensation

2. Make a list of the effects of LA on other tissues.

• Tongue numbnees and a metallic taste
• Cardiotoxicity
• Neurotoxicity

3. What is the basis for the selection of a LA?

• Dosage
• Site of administration
• Surgery to be performed
• Postoperative pain
• Potential toxic effects

4. Why are LA solutions sometimes saturated with CO₂? 

• LA solutions are saturated with CO₂ so that its effects are potentiated because CO₂ can act as a buffer

5. Which of the LA are typically used for surface anaesthesia?

• Procaine
• Benzocaine
• Cocaine