Cardiovascular System

Central Nervous System

Renal System

Hepatic System

Uterus System

Respiratory System

Halothane

• Decreased blood pressure.
• Sensitizes myocardium for arrhythmic effects of catecholamines.
• Depress normal cardiac contractility.

• Rapid smooth muscle induction
• Increased cerebral blood flow.
• Increased intra-cranial pressure

• Glomerular filtration is decreased.
• Decreased urine flow.

• Hepatotoxicity may occur

• Decreased muscle contraction.
• External rotation of baby.

• Drug of choice, no: cough, saliva, or bronchial secretions.

Enflurane

• Lower blood pressure
• No sensitisation of myocardium.

• Rapid smooth muscle induction.
• Contra-indicated in epilepsy patients. Can cause convulsions.

• Glomerular filtration is decreased.
• Decreased urine flow.

-

-

• More respiratory suppression than halothane.

Isoflurane

• Less blood pressure suppression than halothane and enflurane.
• No sensitisation of myocardium.

• More rapid induction than halothane.
• Quicker recovery than halothane.

• Glomerular filtration is decreased.

Decreased urine flow.

-

-

• Potent skeletal muscle relaxing effect.

Desflurane

• Lower supressing effect than halothane and enflurane.

• Quicker induction than isoflurane
• Quicker recovery than isoflurane
• Increase cerebral blood flow.
• Increased intra-cranial pressure.

• Glomerular filtration is decreased.
• Decreased urine flow.

-

-

• Cause irritation to airway.
• Causes cough and shortness of breath.

Sevoflurane

• Lower supressing effect than halothane and enflurane.

• Quicker induction than isoflurane
• Quicker recovery than isoflurane
• Increase cerebral blood flow.
• Increased intra-cranial pressure.

• Glomerular filtration is decreased.
• Decreased urine flow.

-

-

• Less irritating to airway than desflurane.

Nitric Oxide

-

• Potent analgesic
• Weak anaesthetic effect
• Fast recovery

• Glomerular filtration is decreased.
• Decreased urine flow.

-

-

• Can lead to hypoxia