Migraine headache is a recurrent throbbing headache that typically affects one side of the head and is often accompanied by nausea and disturbed vision.

pathology of migraine it is caused by the dilation and inflammation of cephalic arteries and intracranial extra cerebral arteries.

Serotonin: Sumatriptan, Naratriptan, Busiproon, and Eltriptan, these medications increase intracranial vasodilation.They act as partial agonists for 5-HT1A, B, and D receptors.
Acute migraines are treated with these medications and they are first line of treatment.

Ergotamine and dihydroergotamine : Ergotamine is used to treat acute migraines and headaches.
It's a partial agonist for 5HT2, Alpha, and central dopamine receptors that's mixed.
These medications have a vasoselective effect.
Smooth muscle contraction and vasoconstriction are caused by this medication, which helps to relieve migraine symptoms

Calcium blockers and beta blockers : Propranolol reduces intensity and frequency of migraine. Metoprolol, Timolol and Atenolol also give the same efficacy

Verapamil: considered to have modest efficacy as prophylaxis against migraine