Paracetamol is a weak cyclo-oxygenase (cox) COX 1 and COX 2 inhibitor in the peripheral
tissue. This is why it does not show anti-inflammatory effects. Paracetamol also inhibits the
COX 3 enzyme located in the central nervous system. If the COX 3 is blocked, it will activate the decreasing serotonergic analgesic pathways. Paracetamol is also antipyretic because it works directly on the hypothalamic thermoregulation center and then lowers the fever.
Aspirin is an irreversible, non-selective COX 1 and COX 2 blocker. It lowers prostaglandin,thromboxane and prostacyclin production in the body. Aspirin is then also used to lower
platelet adhesion, it is also antipyretic, analgesic and then has hyo ok anti-inflammatory
effects.
Although it is said that aspirin and paracetamol are the same, it is completely wrong.
Paracetamol does not have anti-inflammatory or anti-platelet adhesion properties.
Paracetamol is useful for use in mild to moderate pain such as headaches, postpartum
pain and myalgia where aspirin is also an effective analgesic. Paracetamol is also
recommended for use in moderate pain if the patient is allergic to aspirin. A patient with a peptic ulcer and someone who has aspirin tightened his chest will also need to use paracetamol for pain and fever, as well as a patient who tends to hemophilia.
Nausea and vomiting, constipation and abdominal pain, skin rash and urticaria and acute
liver failure and jaundice. Bloody, black stools and dark urine.
The liver enzymes catabolize conjugation of paracetamol. When the enzymes are saturated, toxic NAPQI forms. NAPQI is deactivated by glutathione BUT if glutathione levels are
depleted it causes NAPQI necrosis.in the liver and kidney tubes. A fatal dose can be 10-15g per day.This is between 20 and 30 tablets. If a patient experiences a lot of pain and
thinks that paracetamol is very safe, someone can very easily take so many pills for pain
and not even realise how toxic it is. The normal adult dose is only 4g per day.
Unfortunately, the symptoms of paracetamol poisoning take a long time and you can only
experience nausea and vomiting, stomach pain, decreased appetite, fatigue and
weakness within 1-2 days after the overdose. After 1-2 days the big trouble comes and
you may experience symptoms like right subcostal pain, tender liver and jaundice. Then
renal insufficiency can occur, then liver necrosis and then death. The treatment of acute
toxicity should happen vining. The treatment for acute toxicity is poorly effective for the first10 hours after poisoning. Within the first hour after poisoning, you should try to induce
vomiting, you can do a gastric lavage and one can use activated carbon as IV treatment,
The patient needs immediate supplementation of the sulfhydryl group to produce
glutathione in the liver fill to prevent liver cell necrosis - acetylcysteine should be
administered in IV within 8-12 hours. The initial dose is 150mg / kg in 200ml 5% glucose
over 15 minutes, then 50mg / kg in 500ml 5% glucose over 4 hours and then 100mg / kg in1000ml 5% glucose over the next 16 hours.
Oral treatment can also be administered by acetylcysteine at 140mg / kg or carbocystine
at 150mg / kg.