Migraine can be considered as a severe headache but is characterised by vasodilation of intracranial arteries via vasodilators such as CGRP, causing oedema and stimulating pain nerve endings. Treatment of migraine will therefore need to include analgesia (for pain treatment, eg paracetamol and aspirin), anti-inflammatory drugs (NSAIDs) and vasoconstrictors (ergotamine). NSAIDs block the production of mediators which stimulate pain receptors while ergotamine relieves vasodilatory effects in the intracranial arteries via vasoconstriction.