1.    Endothelium-dependent vasodilation is vasodilation initiated by endothelial cells.
2.    Constitutive form of NOS is found in endothelial cells while the inducible form is found in macrophages. Constitutive NOS enzyme is always produced regardless of the metabolic state of the body while an inducible NOS enzyme is produced situationally. 
3.    Indirect release of NO by stimulation of PG via COX2 in inflammatory response leads to vasodilation and a further decrease in blood pressure occurs, increasing the severity of septic shock.
4.    Substance P, neurokinin A and B and endothelins.
5.     NO can be inhibited by hemoglobin and excreted in the kidneys.
6.    Tissue damage releases NO and indirect release is also stimulated by PG release leading to vasodilation and allowing migration of neutrophils to affected areas. This can be a disadvantage in inflammatory conditions such as arthritis. 
7.    Alzheimer’s disease, anxiety, and depression.