1. There is little doubt that the pathology of migraine depends strongly on a vascular component.  Both vasoconstrictors and vasodilators are effective in some cases of migraine.  Furthermore, even though vasoconstrictors are effective in migraines, it does not mean that drugs that cause vasodilation are necessarily the culprits which precipitate migraines.  It appears that migraine comprises far-reaching changes in vascular functions, which are unpredictable, especially if we take into consideration that anti-inflammatory drugs which have no direct vasoactive action, are also effective.  Read the part on the treatment of migraine (Katz).  Prepare a rationalisation of the pathology of migraine as well as current treatments and how they work and submit in as a blog summary.  

The involvement of trigeminal nerve distribution to intracranial arteries, with release of powerful vasodilators (CGRP) that cause vasodilation and oedema, that activating pain nerve endings.

Treatment :

Sumatriptan - activate 5-HT1B receptors, vasoconstriction of cranial nerves

Prophylaxis - flunarazine is a calcium ion blocker

                     propanalol is a beta blocker