ANECHIA DE BEER

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Blog #8

19 Mar 2021, 17:06 Publicly Viewable
  • Compile a table, listing the major effects on every system (cardiovascular, CNS, renal, hepatic and uterus) for all the inhalation anaesthetics. This table is important when it comes to the selection of drugs in certain individuals.

Halothane:

Central Nervous system:

  • Causes fast and smooth induction
  • Increases cerebral blood flow
  • Increases intracranial pressure

Autonomic system:

  • Causes Bradycardia

Cardiovascular system:

  • Decreases blood pressure
  • Causes a sensitized myocardium for arythmogenic effects of the catecholamines

Respiratory system:

  • No saliva, bronchial secretions, or coughing

Musculo-skeletal:

  • Skeletal muscle relaxing effects
  • Increases action non-depolarization
  • Decreased action depolarization
  • Post-operative shaking due to hypoxia

Uterus:

  • Decreased muscle contractions
  • External twisting of a baby

Liver:

  • Hepatotoxic effects (unpredictable and can be very rare)

Enflurane:

Central Nervous system:

  • Fast, smooth induction convulsions sometimes (not epileptic convulsions)

Cardiovascular system:

  • No sensitization of the myocardium.
  • Less suppression than Halothane

Respiratory system:

  • More suppression than Halothane

Isoflurane:

Central Nervous system:

  • Faster induction
  • Faster recovery than Halothane

Cardiovascular system:

  • Less suppression than Halothane
  • No sensitization of the myocardium

Respiratory system:

  • Potent suppression effects

Desflurane:

Central Nervous system:

  • Even faster induction than Isoflurane
  • Even faster recovery compared to Isoflurane
  • Increased cerebral blood flow and intracranial pressure

Cardiovascular system:

  • Less suppressing effects compared to Halothane and Enflurane

Respiratory system:

  • Strong smell that irritates airways
  • When used as an induction drug it may cause coughing, shortness of breath and a laryngospasm

Sevoflurane:

Musculo-skeletal:

  • Potentiates the effects of the non-depolarising muscle relaxants like the other halogenated ethers.
  • Has effects similar too Desflurane with less airway irritation

Nitrous Oxide:

Central Nervous system:

  • Weak anaesthetic effects
  • Potent analgesic effects
  • Amnesia

Cardiovascular system:

  • No effects

Respiratory system:

  • Pure Nitrous oxide results in hypoxia
  • Always mix with oxygen or air
  • Recovery phase: fast diffusion from the blood to the alveoli

Musculo-skeletal:

  • No skeletal muscle relaxation

  • Name the major acute toxic effects of the inhalation drugs.
  • Hepatotoxicity
  • Hypoxia
  • Malignant hypothermia
  • Nephrotoxicity

Brand, L. 2021. General Anesthetics. Study Unit 5 [PowerPoint Presentation]. Unpublished Lecture Notes on eFundi.  FKLG 312. Potchefstroom:NWU