HALOTHANE

ENFLURANE

ISOFLURANE

SEVOFLURANE

DESFLURANE

NITRIC OXIDE

CARDIOVASCULAR

SYSTEM

Decreased blood pressure.

Sensitizes myocardium for arrhythmic effects of catecholamines.

Depress normal cardiac contractility

BRADYCARDIA

Lower blood pressure

No sensitisation of myocardium

Less blood pressure suppression than halothane and enflurane.

No sensitisation of myocardium.

Lower supressing effect than halothane and enflurane.

Lower supressing effect than halothane and enflurane

None

CENTRAL NERVOUS SYSTEM

Rapid smooth muscle induction

Increased cerebral blood flow.

Increased intra-cranial pressure

Rapid smooth muscle induction.

Contra-indicated in epilepsy patients. Can cause convulsions

More rapid induction than halothane.

Quicker recovery than halothane.

induction than isoflurane

Quicker recovery than isoflurane

Increase cerebral blood flow.

Increased intra-cranial pressure

Quicker induction than isoflurane

Quicker recovery than isoflurane

Increase cerebral blood flow.

Increased intra-cranial pressure

Weak anaesthetic effect, potent analgesic, amnesia

Fast recovery phase

RESPIRATORY SYSTEM

Drug of choice if patients has airway problems because it causes no:

Saliva, bronchial secretions, or cough

Causes more respiratory suppression than Halothane.

Pungency effect makes drug less suitable for induction of anaesthesia in patients with active bronchospasm.

Potent supressing effect.

Strengthens due to potent skeletal muscle relaxing effect

Less irritating to airway than desflurane.

Strong smell irritates airway if used as an induction drug.

Causes: Cough, shortness of breath, and laryngospasms.

Can lead to hypoxia thus needs to be used in combo with oxygen.

UTERUS

Decreases muscle contraction.External twisting of baby

Hepatoxicity