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Blog #11

27 Apr 2021, 14:46 Publicly Viewable
  1. The three phenothiazine sub-families are: Aliphatic derivatives, Piperidine derivatives and Piperazine derivatives. The aliphatic and piperidine derivatives have low potency and cause severe sedation, anti-cholinergic effects, postural hypotension and they are cardiotoxic. The Piperazine derivatives have a high potency, but it causes weaker anticholinergic effects and less sedation, less cardiovascular effects and does not cause postural hypotension.
  2. Antipsychotics block D2- receptors as well as H1-receptors, cholinergic receptors and alpha1-receptors (to a lesser extent).
  3. Atypical drugs block serotonin 2A-receptors whereas typical drugs block mesolimbic D2-receptors.
  4. Typical drugs block D3-receptors and this causes the risk of extrapyramidal effects to reduce.
  5. The phenothiazines, particularly the piperazine derivatives, have a high incidence of causing extrapyramidal side effects.
  6. The blockage of cholinergic neurons by the aliphatic derivatives cause the autonomic side effects.