RINETTE LOSPER
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Blog#12

17 May 2021, 11:38 Publicly Viewable

Blog #12

  1. Stel m.b.v. jou handboeke ‘n klassifikasie op van die middels wat as antidepressante gebruik word.

Class of Drugs

Examples of Drugs
  1. Tricyclic Antidepressants (TCA’s)

Tertiary Amines:

  • Amitriptyline
  • Imipramine
  • Trimipramine
  • Chlorimipramine
  • Dothiepine
  • Butriptyline

Secondary Amines:

  • Nortripyline
  • Desimipramine
  • Lofepramine
  1. Monoamine Oxidase Inhibitors (MAOI’s)

Non-selective: Tranylcypromine

MOA-A selective: Moclobemide

Other: Isocarboxazid, Phenelzine, Selegiline
  1. Serotonin-norepinephrine Reuptake Inhibitors (SNRI’s)

Venlafaxine

Desvenlafaxine

Duloxetine
  1. 5-HT2 Antagonists

Trazadone

Nefazodone
  1. Selective Noradrenaline Reuptake Inhibitors

Reboxetine
  1. Tetracyclic and Unicyclic

Tetracyclic:

  • Mianserin
  • Mirtazepine

Unicyclic:

  • Bupropione
  1. Circadian Rhythm Regulator

Valdoxane
  1. Selective Serotonin Reuptake Inhibitors (SSRI’s)

Citalopram

Fluoxetine

Paroxetine

Sertraline

  1. Met betrekking tot die bestaande middels se werkingsmeganismes, wat het hulle almal in gemeen?
  • Alle anti-depressante het ’n veelvoudige multipotente werking op baie monoamienergiese reseptore agv. Non-spesifieke verhoging in seretonien of noradrenalien.
  1. Hoe lank neem dit vir hierdie middels se antidepressiewe effekte om te verskyn?  Wat is die rede hiervoor?
  • 6-8 weke dit het ’n baie stadige aanvang van werking. Agv die tyd wat dit neem om op seretonien reseptore in te werk.
  1. Hoe verskil die TAD’e en die selektiewe serotonienheropname remmers (SSRI’s) van mekaar t.o.v.:

TAD

SSRI’s

Effektiwiteit

Drugs need to be titrated to minimum effective dose.

Drugs can be started at full dose.

Newe effekte

Anticholinergic side effects, sedation, weight gain, sexual effects and discontinuation syndrome.

Nausea, GI-upset, diarrhea, decrease in sexual function and interest, headaches and insomnia/hypersomnia, weight gain and discontinuation syndrome.

Veiligheid

Not safe in overdose; the most commonly used drugs used in suicide. Causes lethal ventricular arrythmias and fibrillation as well as seizures.

Very safe with regards to overdose
  1. Hoe werk mirtasepien?
  • Blokkeer α 2, 5HT-2A, 5HT-2C en 5HT-3 reseptore.
  1. Hoe werk venlafaksien?
  • Antagoneer Seretonien en NA (Nor- adrenalien) se trasport.
  1. Hoe werk agomelatien?
  • Blokkeer  5HT-2C reseptore waar dit terselfde tyd die  MT1/MT2 reseptore stimuleer.