5-HT 1D/1B agonists such as triptans are primarily used for migraines. Migraines can include nausea, vomiting, visual scotomas and even sometimes hemianopsia and speech abnormalities. The common excruciating throbbing in the head can last up to two days. Migraines include trigeminal nerve distribution towards the intra-canal arteries, to which these nerves release peptide neurotransmitters such as Calcitonin gene-related peptides, causing major vasodilator. Drug classes such as Triptans, ergot alkaloids and antidepressants. These drugs activate the 5-HT 1D/1B receptors which inhibit the release of peptides. Other drugs that contain antiseizure agents can decrease the rapid release of neurotransmitters. Analgesicts such as asprine and ibuprofen can help to eliviate the pain aswell. Direct 5-HT agonists can cause vasoconstriction, therefore prevent the vasodilation of the arteries and help subside the stretching of the nerve pain endings.

Other drugs include Propanolol and amitriptyline. Anticonvulsants drugs such as valproic acid and topiramate help alleviate migraines, as well as Verapamil and calcium channel blockers-Flunarizine.