Migraine pathology:  A condition characterized by painful recurring headaches, sometimes with nausea and vomiting. Migraine typically recurs over a period lasting 4 to 72 hours and is often incapacitating. The primary type is migraine without aura (formerly called common migraine). This condition is commonly unilateral (affecting one side of the head), with severe throbbing or pulsating headache and nausea, vomiting, and sensitivity to light & sound

Treatment: 

1. Triptans -  they are selective agonist for 5HT1D and 5HT1B. They have a vasoconstriction action which prevents vasodilation.
2. Ergot alkaloids – activates 5-HT1D and 5-HT1B receptors on presynaptic nerve endings to inhibit the release of vasodilating peptides. 
3. Nonsteroidal anti-inflammatory analgesic agents – helpful in treating migraine pain