DRUG

EFFECT

Halothane

CNS:

• Fast smooth muscle induction. Stadium 2 is absent. This includes excitement delirium, loss of consciousness and amnesia uneven breathing.
• Increased cerebral blood flow can lead to intracranial pressure

ANS: Bradycardia

CVS:

• Decreased Blood pressure

• Sensitized myocardium for arrhythmic effects of catecholamines.

Respiratory System:

•  No Saliva, bronchial secretions, or cough

Musculo-Skeletal:

• Skeletal muscle effects in stage 3.
• Increases action on non-depolarizing muscle relaxants
• Decreases action on depolarizing muscle relaxant.
• Post-operative shaking causes hypoxia, decrease O₂ flow to the tissue

Uterus:

• Decrease muscle contraction

Liver:

• Hepatoxicity

Enflurane

CNS:

• Fast smooth muscle induction.
• Convulsions may occur don’t use in epileptics

CVS:

• No myocardium sensitization
• less than Halothane 

Respiratory System:

• More depression than halothane

Isoflurane

CNS:

• Faster induction and recovery than halothane

CVS:

• Less decrease in blood pressure than Halothane and Enflurane. No sensitization of myocardium.

Respiratory System:

• Potent decrease of the respiratory system. Suppressing effect enhances by skeletal muscle relaxing effects

Desflurane

CNS:

• Faster induction and recovery phase than Isoflurane. Increase cerebral blood flow which can lead to intracranial pressure

CVS:

• Less depressing than enflurane and halothane

Respiratory System:

• Strong smell causes an irritation in the airways. If used for induction May lead to coughs, laryngospasms and shortness of breath.

Sevoflurane

All effects are same as desflurane except

Respiratory System:

• Less irritating than desflurane

Nitric Oxide

CNS:

• Weak anaesthetic effects. Potent analgesic effects

Respiratory System:

• May cause hypoxia and needs to be used in combination with oxygen