Migraine it is a headache disorder characterised by recurrent headaches that are moderate to serve. Last for few hours to 3 days. Its episodes affect the one side of the head, pulsating in nature. Its side effects are nausea, vomiting and sensitivity to light. 

Treatment 

Ergotamine: it is the alpha1 and 5HT agonist. It selectively binds and activates 5HT receptors located on intracranial blood vessels, thereby resulting in vasoconstriction and reducing blood flow in cerebral arteries that may lead to relieve of vascular headaches.

Sumatriptan: It is a 5HT1d agonist. It selectively binds to and activates 5HT1D in the CNS it increases vasoconstriction, counteract vasodilation that causes pain during migraine. 

Aspirin: That inhibits the production of prostaglandin therefore causing an increase in production of leukotriene which causes vasoconstriction. Reducing pain.