MAVERICK NDLOVU

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BLOG #11

26 Apr 2021, 17:37 Publicly Viewable
  1. Aliphatic derivatives: Chlorpromazine

Piperidine derivatives: Thioridazine

Piperazine: Fluphenazine

The aliphatic and piperidine derivatives have a low potency, low EPS, high sedation, high anticholinergic and alpha-lytic effects and cardiotoxicity. The piperazine derivatives have a high potency and EPS but have low sedation, low anticholinergic and alpha-lytic effects and low cardiotoxicity.

  1. The D2- and 5HT2A-receptors are blocked but they have a higher affinity for the D2-receptors, hence they are blocked to a higher extent that the 5-HT2A receptors.
  2. The typical antipsychotics have a higher block the D2-receptors to a higher extent, while the atypical antipsychotics block the 5-HT2A-receptors to a higher extent.
  3. The 5-HT2A-receptors.
  4. Piperazine derivatives of phenothiazines, thioxanthenes, butyrophenones, pimozide. This is due to the fact that they have a high potency for the D2-receptors.
  5. Alpha-1 and muscarinic receptors.