Why do you think aspirin is contraindicated for people with allergic asthma? Because it blocks both COX 1 and 2, more arachidonic acid is available for the production of leukotrienes, thus producing more leukotrienes. This leads to bronchoconstriction, which is not good for asthma patients. Arachidonic acid is the most important precursor of eicosanoids, but how is this fatty acid released from the cell membrane and through what stimulus? For eicosanoid synthesis, arachidonic acid (AA) must first be released from membrane phospholipids. There are at least three classes of phospholipases that contribute to the release of AA from membrane phospholipids. Cytosol PLA2 (phospholipase A2) Secretory PLA2 (calcium dependence) Calcium-independent PLA2 (Chemical and physical stimulation activates Ca2 + translocation of PLA2 to the plasma membrane, where it releases arachidonic acid for the synthesis of eicosanoids.) In addition to prostanoids and leukotrienes, which other nonnicosanoid products of cell membrane hydrolysis are deeply involved in asthma? Why do you say that COX-II inhibitors, not COX-I inhibitors, have a selective effect on the inflammatory response? COX 1: Always present in the body and has housekeeping functions such as cell protection of the gastric epithelium. COX 2: Easy to induce and its level depends on the stimulus. It is often found in kidney and vascular tissue. Release occurs via inflammatory stimuli, shear stresses, and growth factors. Drugs that inhibit any of the following enzymes, such as tumor promoters: Phospholipase A; Cyclooxygenase; Lipoxygenase, Phospholipase A: Hydrocortisone Cyclooxygenase: Aspirin Lipoxygenase: Giroton Prostaglandin and antileukotriene receptors A drug that can act as a target. How does that happen? Cox1 & Cox2 irreversibly block What are the benefits of alprostadil in the treatment of congenital heart disease? This is given to the patient as an infusion to keep the heart valve open during surgery. What is the value of misoprostil in the treatment and prevention of gastric ulcer? It protects the lining of the stomach by increasing mucus production and reducing acid secretion. Prostaglandins may help with asthma. Which PGE2 or PGF2A analog is effective in such cases? Epoprostenol What is the value of latanoprost in the treatment of glaucoma? Increased outflow of aqueous humor.