What is the mechanism of action of colchicine in the treatment of gouty arthritis? colchicine regulates various pro-inflammatory and anti-inflammatory signaling pathways associated with Jigartritis. Colchicine prevents the accumulation of microtubules, thereby interfering with inflammatory activation, microtubule-based inflammatory cell chemotaxis, leukotriene and cytokine production, and phagocytosis. What are the indications for the use of colchicine, its side effects and dosages? Colchicine indications: acute and recurrent pericarditis, prevention of postpericardial syndrome, primary biliary cirrhosis, cirrhosis, dermatitis herpetitis, Paget's disease, chronic immune thrombocytopenia and idiopathic thrombocytopenia Purpura, pseudogout. Side effects of colchicine: Diarrhea, nausea, cramps, abdominal pain and vomiting may occur. If any of these side effects persist or worsen, tell your doctor or pharmacist immediately. The doses of colchicine are: Oral dosage form (capsule, solution): To prevent gout attacks: Adults 0.6 mg (mg) (5 ml [ml]) once or twice daily. However, the dose is usually 1.2 mg or less per day. Oral use (tablets): Prevention of seizures: Adults 0.6 mg (mg) once or twice daily. However, the dose is usually 1.2 mg or less per day. To treat a ziga attack: 1.2 mg (mg) for adults at the first sign of a ziga attack, 0.6 mg 1 hour later. The dose is usually 1.8 mg per hour. What are the other medications that can be used to treat acute gout attacks? Colchicine is an effective anti-inflammatory drug to relieve the pain of gout. Non-steroidal anti-inflammatory drug (NSAID). Which drug group does probenecid belong to? How do the drugs in this group work? Probenecid belongs to a class of drugs called uricosuric drugs. It lowers your body's levels of uric acid by helping the kidneys excrete uric acid. If the uric acid level becomes too high, crystals can form in the joints and cause gout. How does allopurinol work? What are its indications, precautions, and key interactions? Allopurinol works by reducing the amount of uric acid produced by the cells of the body. In gout, it helps prevent uric acid crystals from accumulating in the joints. Prevents joint swelling and pain. Allopurinol is indicated for reduced uric acid / uric acid formation in diseases in which uric acid / uric acid deposition has already occurred or is at foreseeable clinical risk. Take as directed by your doctor. Do not take more often or longer than your doctor recommends. This can increase the likelihood of side effects. You can take this medicine after meals to prevent stomach problems