Drugs used in the treatment of migraines

Serotonin 1B/1D antagonists (Sumatriptan)

Serotonin 1F antagonist (Lasmiditan)

Vasoselective ergotalkaloids (Ergotamine)

Uteroselective ergotalkaloids (Ergonovine)

Vasoconstriction by ergotalkaloids helps when taken early

 

Possible mechanisms:

5-HT 1B/1D receptors on presynaptic trigeminal nerve endings activated to inhibit the release of vasodilating peptides

Vasoconstricting action of 5-HT agonists may prevent vasodilation and stretching of the pain endings

 

Actually: 

Reduction of trigeminal nerve stimulation is what actually prevents the migraine