B COETZEE
BIANCA COETZEE
Blog #8
18 Apr 2021, 15:25
| Drug | CVS | CNS | Respiratory system | Kidneys | Liver | Uterus | |
|---|---|---|---|---|---|---|---|
|
Halothane |
Bradycardia Decreased BP Sensitized myocardium for arythmogenic effects of catecholamines. |
Fast smooth induction; stage 2 absent. Cerebral blood flow. Incr intracranial pressure. |
No saliva; bronchial secretions and cough. | Decrease the glomerular filtration rate and renal blood flow; incr the filtration fraction. |
Hepatotoxic. | Decreased muscle contraction. | |
| Enflurane | No sensitization of myocardium; less suppression than halothane. | Fast, smooth induction. sometimes convulsions | More suppression than halothane. |
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| Desflurane | Less suppression than halothane and enflurane. | Faster induction and recovery than isoflurane. incr cerebral blood flow and intracranial pressure. | Strong smell, can irritate airways and can lead to cough, shortness of breath and laringospams if used as induction drug. |
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| Isoflurane | No sensitization of myocardium; less suppression than halothane and enflurane. | Faster induction and recovery than halothane. | Potent suppressing effect. Strenghtens due to potent skeletal muscle relaxing effects. |
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| Sevoflurane | Less suppression than halothane and enflurane. | Faster induction and recovery than isoflurane. incr cerebral blood flow and intracranial pressure. | less irritation in airways. |
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| N2O |
Weak anesthetic. potent analgesic. can cause amnesia. |
Pure N2O cause hypoxia; always mix with oxygen or air. |
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Major toxic effects:
- Halothane - hepatotoxicity
- Enflurane - Convulsions
- Isoflurane - respiratory suppression
- Desflurane - laringospams
- Sevoflurane - chemically unstable; avoid in patients with liver problems
- nitrous oxide - hypoxia (pure)