• Give a short and critical explanation of the rationale of using fluvoxamine (a selective serotonin reuptake inhibitor (SSRI) in the treatment of Covid patients. Your answer must be properly and appropriately referenced (in-text references as well).

Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) that is approved by the Food and Drug Administration (FDA) for the treatment of obsessive-compulsive disorder and is used for other conditions, including depression, but Fluvoxamine is not FDA-approved for the treatment of any infection.

In a murine sepsis model, fluvoxamine was found to bind to the sigma-1 receptor in immune cells, resulting in reduced production of inflammatory cytokines.¹ In an in vitro study of human endothelial cells and macrophages, fluvoxamine reduced the expression of inflammatory genes. but there not been sufficient proof on whether the anti-inflammatory effect on nonclinical studies same applies to human. therefore there has not been any proof that indeed fluvoxamine may help in the treatment of covid-19

(National institute of health).2021.http//www.covid19treatmentguidelines.nih.gov/therapies/immunodulators/fluvoxamine/ date of access:23 oct 2021