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NDZALAMA MALULEKE

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Blog 8

8 Apr 2021, 22:12 Publicly Viewable

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Compile a table, listing the major effects on every system (cardiovascular, CNS, renal, hepatic and uterus) for all the inhalation anesthetics.

Inhalation drug	Cardiovascular	CNS	Renal	Hepatic	Uterus
Halothane	Decrease BP Sensitized myocardium for arythmogenic effects of catecholamines	Fast smooth induction Stadium II absent Increase cerebral blood flow Increase intracranial pressure	Decrease glomerular filtration rate	Hepatoxicity	Decrease muscle contractions Results in external twisting of baby
Enflurane	No sensitization of the myocardium Less decrease than halothane	Fast smooth induction Convulsions sometimes	Decrease glomerular filtration rate	Concentration dependent decrease in portal blood flow	Uterine muscle relaxation
Isoflurane	No sensitization of the myocardium Less decrease than halothane and enflurane	Faster induction and recovery than halothane	Decrease glomerular filtration rate	Concentration dependent decrease in portal blood flow	Uterine muscle relaxation
Desflurane	Less decrease than halothane and enflurane	even faster induction and recover than isoflurane Increase cerebral blood flow and intracranial pressure	Decrease glomerular filtration rate	Concentration dependent decrease in portal blood flow	Uterine muscle relaxation
Sevoflurane	same as desflurane	same as desflurane	Decrease glomerular filtration rate	Concentration dependent decrease in portal blood flow Undergoes metabolism and is chemically unstable	Uterine muscle relaxation
N₂O		Weak anaesthetic Potent analgesic Amnesia	Decrease glomerular filtration rate

Name the major acute toxic effects of the inhalation drugs

Nephrotoxicity
Hematotoxicity
Malignant hyperthermia
Hepatotocixity