Name an example of each of the three phenothiazine sub-families and state how they differ from one another in terms of potency and side effects.

Chlorpromazine as an aliphatic side chain.

Periciazine has a piperidine side chain.

Fluphenazine has a piperazine side chain.

Both aliphatic and piperidine compounds has a low potency and is highly sedative and has a strong anti-cholinergic effect and has strong alpha lytic effects (is cardiotoxic) while piperazine has a high potency with weak anti cholinergic side effects and weak alpha lytic effects.

Which receptors in particular are blocked by the typical antipsychotic drugs?

Block dopamine 2 receptors in the mesolimbic

How does the mechanism of action of the atypical drugs differ from that of the typical drugs?

A atypical drug differs from a typical drug because it blocks serotonin 2A receptor more than dopamine 2 receptors unlike typical drug that selectively blocks dopamine 2 receptors.

Which of the receptors blocked by the older drugs reduce the risk of extrapyramidal side effects?

Older drugs (Typical drugs) such as Chlorpromazine and periciazine has little extra pyramidal side effects both of these blocks mesolimbic dopamine 2 receptors.

Which of the older drugs have a high incidence of extrapyramidal side effects? What is the reason for this?

Older drugs (Typical drugs) such as Fluphenazine, perphenazine, trifluoperazine and prochlorperazine as high extra pyramidal side effects because these drug as an long halve life an is extremely potent.

Because of which receptor(s) blockade do the aliphatic group of drugs have a high incidence of autonomic side effects?

Muscarinic and histamine receptor blockage caused the side effects on the autonomic system.