MAVERICK NDLOVU
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blog #7
19 Mar 2021, 18:04
- Phenobarbitone, phenytoin and carbamezapine. The contraceptive levels may be reduced by these strong inducers thus leading to the failure of the contraceptive drugs. Non-enzyme inducing drugs or drugs that do not have any interactions and are excreted via the kidney such as gabapentin.
- Yes, they can.
- Neonates have a relatively slow metabolism of anti-epileptic drugs because their metabolic systems are underdeveloped at the time. Babies and children have a faster metabolism than adults. Geriatrics require a low dose because the level of function of their metabolism has deteriorated.
- In drugs that have a narrow therapeutic index, when using the combination of valproate and lamotrigine and when phenytoin undergoes zero-order kinetics