1. Which of the anti-epileptic drugs affect the metabolism of the Pill (oral contraceptive) and what are the implications of this? Which drugs are safe to use in combination with the Pill?

Perampenel (decreases the efficacy of levonorgestrel-containing contraceptives) and Phenobarbitone, phenytoin, carbamazepine, and oxcarbazepine all reduce the effectiveness of the oral contraceptive pill, resulting in more births and the risk of teratogenic effects in these pregnancies. Valproate, Lamotrigine, Gabapentin, Levetiracetam, and Vigabatrin are all safe to take together.

2. Can oral contraceptives also affect the effectivity of the anti-epileptic drugs?

Yes, oral contraceptives can lower the levels of drugs like Lamotrigine and Valproate in the blood.

3. How does age affect the kinetics of these drugs (from neonates to old age)?

Since neonates have a slower metabolism, they should be given lower doses. Since babies and children's metabolisms are quicker than adults', they should be given higher doses. Because of their slower metabolism and reduced renal activity, geriatric patients need lower dosages.

4. In which cases is plasma blood level monitoring indicated?

Chronic kidney failure, liver disorders, hypoalbuminemia, burns, pregnancy, malnutrition, age, and the use of displacement drugs are all examples of where protein binding occurs and some diseases that may cause protein binding. Plasma blood level monitoring is needed in these situations.