• How does the sensitivity for blockade by a LA compare regarding the following types of fibers:

1. myelinated fibers with unmyelinated fibers:

small and myelinated fibers are easily blocked than unmyelinated fibers.

2. pressure/touch nerves with the dorsal nerves that transmit pain impulses?

Activated pain fibers fire faster, pain sensation selectively blocked by LA.

• Make a list of the effects of LA on other tissues.

• Skeletal muscles: weak blocking action
• Heart: class 1 anti-arrhythmic drug

• What is the basis for the selection of a LA?

Is the LA for small surgical procedures, spinal anesthesia or post-operative analgesia

• Why are LA solutions sometimes saturated with CO₂?

To potentiate the effects of LA

• Which of the LA are typically used for surface anaesthesia?

              Cocaine, benzocaine, oxybuprocaine