Name an example of each of the three phenothiazine sub-families and state how they differ from one another in terms of potency and side effects.

Aliphatic side chain e.g. Chlorpromazine and Piperidine side chain e.g. periciazine, both have a  low potency with little EPS, severe sedation, strong anticholinergic effects, strong α-lytic effects and cardiotoxicity.

While piperazine side chain e.g.  Fluphenazine, has a high potency, more EPS, weaker anticholinergic effects, weaker α-lytic effects, less cardiovascular effects and less sedation.

Which receptors in particular are blocked by the typical antipsychotic drugs?

DA, M, α, and histamine and serotonin

How does the mechanism of action of the atypical drugs differ from that of the typical drugs?

Typical drugs block mesolimbic D₂  receptors, while atypical  block 5-HT_2A  receptors more than D₂ receptors.

Which of the receptors blocked by the older drugs reduce the risk of extrapyramidal side effects?

D₂  receptors

Which of the older drugs have a high incidence of extrapyramidal side effects? What is the reason for this?

Piperazine side chains such as fluphenazine, perphenazine, trifluoperazine and prochlorperazine due to their high potency. 

Also Haloperidol due to it's potent D₂ blockage.

Because of which receptor(s) blockade do the aliphatic group of drugs have a high incidence of autonomic side effects?

Alpha receptors