MH SAGIR

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M SAGIR

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19 Apr 2021, 00:20 Publicly Viewable


Halothane:

Central Nervous system:

  • Causes fast and smooth induction
  • Increases cerebral blood flow
  • Increases intracranial pressure

Autonomic system:

  • Causes Bradycardia

Cardiovascular system:

  • Decreases blood pressure
  • Causes a sensitized myocardium for arythmogenic effects of the catecholamines

Respiratory system:

  • No saliva, bronchial secretions, or coughing

Musculo-skeletal:

  • Skeletal muscle relaxing effects
  • Increases action non-depolarization
  • Decreased action depolarization
  • Post-operative shaking due to hypoxia

Uterus:

  • Decreased muscle contractions
  • External twisting of a baby

Liver:

  • Hepatotoxic effects (unpredictable and can be very rare)

Enflurane:

Central Nervous system:

  • Fast, smooth induction convulsions sometimes (not epileptic convulsions)

Cardiovascular system:

  • No sensitization of the myocardium.
  • Less suppression than Halothane

Respiratory system:

  • More suppression than Halothane

Isoflurane:

Central Nervous system:

  • Faster induction
  • Faster recovery than Halothane

Cardiovascular system:

  • Less suppression than Halothane
  • No sensitization of the myocardium

Respiratory system:

  • Potent suppression effects

Desflurane:

Central Nervous system:

  • Even faster induction than Isoflurane
  • Even faster recovery compared to Isoflurane
  • Increased cerebral blood flow and intracranial pressure

Cardiovascular system:

  • Less suppressing effects compared to Halothane and Enflurane

Respiratory system:

  • Strong smell that irritates airways
  • When used as an induction drug it may cause coughing, shortness of breath and a laryngospasm

Sevoflurane:

Musculo-skeletal:

  • Potentiates the effects of the non-depolarising muscle relaxants like the other halogenated ethers.

  • Has effects similar too Desflurane with less airway irritation

Nitrous Oxide:

Central Nervous system:

  • Weak anaesthetic effects
  • Potent analgesic effects
  • Amnesia

Cardiovascular system:

  • No effects

Respiratory system:

  • Pure Nitrous oxide results in hypoxia
  • Always mix with oxygen or air
  • Recovery phase: fast diffusion from the blood to the alveoli

Musculo-skeletal:

  • No skeletal muscle relaxation

  • Name the major acute toxic effects of the inhalation drugs.
  • Hepatotoxicity
  • Hypoxia
  • Malignant hypothermia
  • Nephrotoxicity