TANELLE TRUSLER
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TANELLE TRUSLER

BLOG #11

30 Apr 2021, 00:08 Publicly Viewable
  1. The three phenothiazine sub-families are Aliphatic derivatives, Piperidine derivatives, and Piperazine derivatives. The aliphatic and piperidine derivatives have low potency and cause severe sedation, anticholinergic effects, postural hypotension, and they are cardiotoxic. The Piperazine derivatives have high potency, but it causes a weaker anticholinergic effect and less sedation, less cardiovascular effects, and does not cause postural hypotension.
  2. Antipsychotics block D2- receptors as well as H1-receptors, cholinergic receptors, and alpha1-receptors. (> alpha 1 receptors)
  3. Atypical drugs block serotonin 2A-receptors. Typical drugs block mesolimbic D2-receptors.
  4. Typical drugs block the D3-receptors and this causes the risk of extrapyramidal effects to reduce.
  5. The phenothiazines, particularly the piperazine derivatives, have a higher incidence of causing extrapyramidal side effects.
  6. The blockage of cholinergic neurons by the aliphatic derivatives causes autonomic side effects.