FARHIN DELAWALA
Blog #8
15 May 2021, 20:39
- Compile a table, listing the major effects on every system (cardiovascular, CNS, renal, hepatic and uterus) for all the inhalation anaesthetics. This table is important when it comes to the selection of drugs in certain individuals.
|
Systems |
Halothane |
Enflurane |
Isoflurane |
Desflurane |
Sevoflurane |
N20 |
|
Cardiovascular |
Decreased blood pressure, sensitized myocardium for arythmogemic effects of catecholamines. |
No sensitisation of the myocardium |
Lower than Halothane and Enflurane, no sensitisation of myocardium |
Lower than Halothane and Enflurane |
Similar to Desflurane |
No effect |
|
CNS |
Fast smooth induction, stadium ll absent |
Smooth induction in rare case convulsions may occur (epilepsy) |
Faster induction and faster recovery than Halothane |
Faster induction and recovery than Isoflurane, increases the cerebral blood flow and intracarnial pressure |
Similar to Desflurane |
Weak anaesthetic, potent analgesic, amnesia |
|
Renal |
Decrease urine flow. |
Decrease urine flow and glomerular filtration takes place |
Decrease urine flow |
Decreases urine flow in the kidney |
Decrease urine flow |
Decrease urine flow and glomerular filtration takes place |
|
Hepatic |
Hepatotoxic in the liver (in rare case) |
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Uterus |
Decrease muscle contractions thus external twisting of baby occurs. |
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- Name the major acute toxic effects of the inhalation drugs.
- Nephrotoxicity
- Hypoxia
- Malignant hypothermia
- Hepatotoxicity
Brand, L. 2021. General anaesthetics. Study unit 5 [PowerPoint Presentation]. Unpublished lecture notes on eFundi, FKLG312. Potchefstroom: NWU