Give a short and critical explanation of the rationale of using fluvoxamine (a selective serotonin reuptake inhibitor (SSRI) in the treatment of Covid patients

Fluvoxamine is a particular serotonin reuptake inhibitor that is used for the treatment of obsessive-compulsive disorder and is used for different conditions like depression. Fluvoxamine isn't FDA-supported for the treatment of any infection.

In a murine sepsis model, fluvoxamine was found to bind to the sigma-1 receptor in immune cells, resulting in a decrease in the production of inflammatory cytokines. In an in vitro study of human endothelial cells and macrophages, fluvoxamine decreased the expression of inflammatory genes. More examinations are needed and expected to establish whether the anti-inflammatory effects of fluvoxamine observed in nonclinical studies also occur in humans beings and are clinically applicatble in the treatment of covid 19 in patients. However, more research and tests have to be done to promote Healthcare, efficacy and safety.