Give a short and critical explanation of the rationale of using fluvixamine in treatment of covid 19?

Fluvixamine is a selective serotonin inhibitor that is used for the treatment of obsessive compulsive disorder and depression. It can also be used in covid 19 patients due to its anti-inflammatory effects. It has an affinity for binding to sigma 1 receptor in immune cells, resulting in reduction of the production of inflammatory cytokines( NIH. 2021).

References 

NIH. 2021.http://www.covid19treatmentguidelines.nih. Date of access: 20 October 2021.

1) angiotensinogen levels are increased during pregnancy and estrogen containing oral contraceptives, which increases blood pressure and might lead to stroke.

2) because the blockade of ANG receptors doesn't interfere with the inhibition of bradykinin. Which causes dry cough, headaches etc. 

3) ace inhibitors block the conversion of ANG 1 and 2 and it also Inhibits the breakdown of bradykinin which decreases blood pressure. 

4) AT1 receptors, yes they do have a direct effect on ANG 2.

5) kinins cause vasodilation and arterious dilation, Decreasing peripheral resistance and blood pressure. Bradykinin camp, NO, IP3, prostaglandins etc. 

Natriuretic peptides also cause vasodilation and arterious dilation. 

6) B2 receptors. 

7) Natriuretic peptides are used in heart failure, because they limit sodium retention via increasing glomerula filtration and Decreasing the proximal tubular sodium reabsoption. 

8) neprilysin is the enzyme that breaks down Natriuretic, it's antagonist is sacubitril that increases the circulating levels of Natriuretic peptides, limiting sodium reabsoption in heart failure. 

9) vasodilators- PGI2 AND NO

Vasoconstrictor- endotheluns

1) via endothelium dependent vasodilation, increasing calcium levels leading to the release of EDRF, which releases Nitric oxide.

2) a constitutive enzyme is constantly synthesized and persist in one area. Induced enzyme, they need to be stimulated first for them to work and their effects are small.

3) nitic oxide causes vasodilation which leads to decrease in blood pressure in high doses it might lead to hypotension. Sepsis in an inflammatory response to infections, Induces INOS macrophage leading to severe hypotension and shock. 

4) nitric oxide

5) via Nos enzymes inhibition to arginine. 

6) nitric oxide is released due to tissue injury leading to inflammatory actions or via the PG synthesis via COX-2.

7) by acting as a neurotransmitter in the brain, used in the treatment of Parkinsonism and stroke. 

Serotonin 1D/1A - play a role in migraines by stimulating smooth muscles in the intracranial blood vessels, causing vasoconstriction and preventing vasodilation that leads to a migraine.

Ergots- they are partial agonists at alpha and serotonin receptors, they also play a role in prophylaxis and preventing acute attacks of migraine. 

Anti - inflammatory drugs can also be used for pain, associated with migraines such as ibuprofen and aspirin. 

Other drugs that can be used are, beta blockers and calcium channel blockers..